I took a Bob on tour. On level ground it was fine. I often would check my mirror after a stop to make sure I had remembered to re-attach it. However, as soon as I got on a substantial hill, I knew it was there. I started referring to it in my head as "the anchor." After that tour I went back to panniers.
If I had a bike that wasn't able to mount panniers, I'd still use the Bob, but since my LHT is made for racks and panniers my Bob has been assigned to shopping duties around home.