I weigh around 185 and have ridden both radial front wheels with 20 spokes and 3 cross with 32 spokes. I have also ridden rear with radial on the non drive side and 2 cross on the drive side as well as 32 spoke 3 cross rear wheels. I have never had a problem with any of them. IMO, it is more the quality of what you put into the wheel and the build quality that really affects it as long as you aren't planning on going to a very low spoke count or being extremely rough on them, but YMMV. I have always been lucky and not had any problems with wheels except when a car hit one and it went out of true enough that it was rubbing on the chainstay.