Indeed I do. My choice would be to ride hwy 6 from Tobermory to Guelph, link up with old hwy 24 (not sure what it's called now, I'll hafta look it up) south to Cambridge, catch hwy 8 east to hwy 5, east to Waterdown, south on Mill St, (becomes Waterdown Rd), east on Plains rd, (becomes Fairview St),south on Brant St to the waterfront.
Most of the big hills you'll encounter are downhills, and there are some really nice small towns on this route.