From my years of shop experience:

1. Once the dropout faces get messed up/galled your screwed as the locknut and skewer will always want to migrate back to their original positions. Sometimes resurfacing with a file is needed.
2. Axles should extend 1/2 to 2/3 across the width of the dropout. File axle ends as needed.
3. Use only high quality skewers with internal cam mechanisms.
4. Thoroughly grease/lub the cam mechanism.