Another vote for the Arkel Commuter. Great bag; lots of pockets for little bits & pieces, laptop pouch, and cavernous enough to hold textbooks, extra clothes, and just about anything else I need to take to work (I'm a student on a clinical placement). Waterproof zippers, Cordura fabric, and a great mounting system, too.

I also use a Topeak MTX TrunkBag EX. I use it exclusively as my lunch bag; I work 12-hour shifts and it gives me enough room for all my food, and the reusable plastic containers that it comes in. I also love the way in integrates with my Topeak rack. Slicker than owl sh*t, as my pappy was fond of saying.

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