Have you considered the historic Lincoln Highway - the first transcontinental highway?
The Ohio sections have almost all been bypassed by newer four-lane stretches of US 30.
There are strip maps of all parts in Ohio.

http://www.lincolnhighwayoh.com/preface.html
Each section is listed in the left column.
Strip Maps and mileages are clickable on the bottom of each page.

You can connect with the Northern Tier in the super bike-friendly town of Monroeville, Indiana.

You will need to find an alternate route from Lisbon to Canton as the new highway has not been built and the old road carries oodles of traffic. OH 172 is one option. Similarly, west of Canton the stretch from Massillon to East Union is tricky. There is a bike trail from Massillon to Dalton, but then you are forced onto 4-lane US 30 - - thus taking Wooster Rd/ Church Rd might be better.

On the west end, I think taking the pre-1928 route thru Ada and Lima may prove more interesting. You will need to continue west on Dixon Rd into Indiana to get to Monroeville. (They demolished the Old Lincoln Highway Bridge just off Dixon Rd that is in the photo - since it was a dead-end stub, I cannot understand why.)

Anyhoo, given the endpoints you mentioned - I think this historic route would be a good choice.