My commute takes me mostly through unexciting, unremarkable neighborhoods. But my weekend rides tend to have me go through a few pockets of Seattle ( and surrounding towns ) that most locals fear. It's really not a big deal. ( On the other hand, our worst neighborhood is nothing like bad parts of, say, the Bay Area. )

The "commuter uniform" ( bright yellow jacket, more lights than a small village, panniers ) will probably attract you some attention, but people will get used to your presence, and start to ignore you. If anyone asks, it all came from Goodwill for a song. But probably no one will ask. Nod at anyone who looks at you, to acknowledge their presence.

Red lights are optional, by the way. If you get nervous, especially in a spot where drugs are being sold, you don't have to stop. If traffic is an issue, turn right, and make the next left to get back on course. You almost certainly won't ever have to escape or evade anybody ... but, if you're nervous, just keep moving.