Originally Posted by
Retro Grouch
The more rear cogs the pickier derailleurs are about having perfect derailleur hanger alignment.
I concur. If you can't tweak the cable tension so you can consistently single-step up and down the gears, it usually means something is bent. Usually it's the derailleur hanger, sometimes it's the derailleur. Another possibility is a worn out jockey wheel on the derailleur--either it wobbles from side to side on its bushing or the chain can't get properly seated on it.