I would have to agree with PeterPan1. Don't assume that getting a custom frame will get you a proper fit. Having gotten many custom frames over the years it took me half a lifetime to get the right fit finally, and it did not jibe with most of the fitting systems. So I would not recommend going out and getting a $2000 frame until you get to the point that you know what the right fit is. To get there refine your understanding by moving your parts from frame to frame trying changes that you or a fit system claims will be better for you. Buy the frames used. If you bump into the edge of a fit that no production bikes can reach then use a builder like Bob Jackson, half the price of most US builders and a solid quality. Even then you may have to accept some retries. Then when you get the fit right, get your Peter Weigle!
Also modern high-end steel tubing can very much improve ride quality. Some can come close to the weight of carbon frames.