Not sure why you would want a Col de la Vie if you want to run at higher pressure There are many better tires for that. What the CdlV is good at is delivering a terrific ride, good puncture resistance and remarkably good rolling resistance at pressures under 60 psi. That said, I certainly would not worry about 65 psi - but I'd try them at the lower pressure for a while first. They work just fine at 50 psi.