I was having the same problem. Thanks for all the wonderful suggestions but none solved my needs which are essentially the same as the original posters:
> Needs to fit my MacBook Pro, large sketchbook and large U-Lock
> Must look fantastic off my bike. I'm a consultant and style counts. I can't wear anything nylon or sports-style. No colors, no reflectivity. No one should be able to tell its a bike bag. I prefer leather messenger bags for my work attire.
> The mounting system must be secure but get out of the way when its off my bike
> I also wanted it to ship from the US and, preferably, be made in the USA. I've had troubles with customs and bags made in China
Then, I found this bag. Its gorgeous. Exactly the kind of bag I would buy even if it wasn't also a pannier.
Check it out:
Lane Leather Bicycle Pannier Messenger Bag