It is a very real fear that most of us avoid thinking about. We put our lights and reflective bits on, follow the rules, and ride with caution. The truth is no matter how prepared we are as cyclists, there's always a driver not paying attention. All you can do is find a safe route, pay attention, and take your time.
I ride in a manner than prevents a sad phone call to my wife and kids. Ride as defensively as possible without losing the joy of cycling.
Sorry to hear about your coworker, I hope he recovers soon.