Originally Posted by BattleRabbit

I measured up everything I need for work, and it fit comfortably in a backpack. I went with panniers just to keep the stuff off my back to reduce sweat and B/O. Unless you need to carry a LOT of stuff for work beyond a change of clothes, lunch/snacks, and a pair of shoes I don't see any reason panniers won't work. They come in a wide variety of sizes, so if you need to carry a laptop or something that can be pretty easily accommodated.