Originally Posted by
wens
Generally speaking people are asymmetrical. Trying to get an asymmetrical body on a perfectly symmetrical bike doesn't make much sense.
+1. The challenge is to figure out in what direction.

I ride with my saddle straight ahead but have experimented with Cobb's suggestion to rotate it. Some good if not top riders do rotate their saddle a bit. If getting low is the objective which it is on a road bike then pushing the saddle off to the side a bit may afford necessary clearance. I think a cutout saddle accomplishes the same end.
Cheers.