I think I would go with the C&V dream bike. I don't think is is really worth it unless you need strange sizing, or want something really wild, such as Aron's MAX bike.
I think is I were to have something built I might try a Mixte with the Gilco tubing like Colnago uses for the seat and down tubes.
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“One morning you wake up, the girl is gone, the bikes are gone, all that's left behind is a pair of old tires and a tube of tubular glue, all squeezed out"
Sugar "Kane" Kowalczyk