I sit my bones on the wide part of the saddle, just behind the nose that supports the . . . soft tissue. This is on my mountain bike. The saddle I use has a groove down the middle to alleviate pressure there, as I was having numbness problems with the standard saddle.

On my road bikes I tilt a lot more forward, so the front of my pelvis would push the soft tissue into the nose of the saddle. Not good. In order to alleviate that, I use ISM Adamo Road saddles, which have two "prongs" instead of a regular nose. The prongs support my pelvis directly. That kind of a saddle (Cobb is the same way) is designed for triathletes and time triallers who are down in an aero position a lot. They aren't comfortable (for me) to use with an upright position.

You will need to be centered and symmetric on the saddle, or you will get who knows what kind of joint and/or back problem from riding crooked. Read: pain.

Make sure your saddle is mounted level (or as directed by the manufacturer), is at the right height (leg not quite straight at the bottom of the stroke), and is positioned right horizontally (plumb like from kneecap should go through pedal center at 3 o'clock). These are just starting points.