To the OP, No.
SPD-SL uses 3 bolts, not 2. (SPD uses 2, but is not a road cleat system, and most modern road shoes are not outfit to mount an SPD style cleat.)
Most modern road shoes can interchange a Look cleat to an SPD-SL cleat. While you can't use the same cleat interchangeably, you most certainly can use the same shoe to interchange cleats.
Last edited by zac; 05-17-11 at 11:11 AM.