Wulf Berg has maintained a US 50 site for a while as well as a newsletter with periodic email updates: http://www.route50.com/ I was getting his email updates for a while because I'd cycled parts of US 50 in the "loneliest road" part of Nevada and let Wulf know. The general impression I have is that like a lot of roads, there are parts that are fine as a major US routes and other parts where US 50 becomes a major highway with busy, high-speed traffic and few shoulders. So, trying to ride all of US-50 would be an awkward choice at times.