Wulf Berg has maintained a US 50 site for a while as well as a newsletter with periodic email updates:
http://www.route50.com/....
Interesting site. I've lived and/or worked along the northern Virgina stretch of route 50 for most of the past 33 years.
....and other parts where US 50 becomes a major highway with busy, high-speed traffic and few shoulders....
Yep. That's the route 50 I know.
I've thought about driving it coast to coast. Never thought about biking it.