As noted, a good pair of bike shorts provides considerable support and comfort. I find angling the nose of my saddle just slightly down from level is about right for me.
Make sure, as noted, that you're actually sitting on the saddle properly...With your "sit bones" firmly on the most-padded area of the saddle.
As well, make sure the fore-and-aft adjustment of the saddle is correct. Too far forward or too far back can cause problems for your sitting position and your knees as well.