PA Bike Routes are on roads, but may use trails. For instance, Bike Route G uses the Pine Creek Rail Trail and, closer to the Maryland border, the Lower Trail. Combined they total about 70 some miles of the 250 comprising the route.
PA Bike Routes are usually signed very well, and when on roads often have a wide shoulder. Bike Route Y, Pymatuning State Park:
Bike Route G, Pine Creek Rail Trail, at Darling Run. Note the signs:
Bike Route V, south of Hickory Run State Park:
Bike Route L, Hickory Run State Park:
Bike Route G, just south of Waterville. The Pine Creek Rail Trail and Bike Route split here. I suggest you stick to the trail since both it and the Bike Route G end in Jersey Shore.
Bike Route S, on Pughtown Road outside Kimberton:
Bike Route S, just outside Elverson, PA. A right turn connects you to the L Route.
Bike Route L, just outside French Creek State Park: