I ALWAYS use some sort of lube. The BOYS "complain" after about 20 mi if I don't. I guess it's just me, or the hot/humid FLA weather. When I first started riding 2 yrs ago, several people said to "buy the best shorts you can afford, at least $100, and use a chamois creme." I followed their advice on the shorts, but it took a few months for me to listen to the BOYS complaining to step up to the creme.
I've used Utterly Smooth (too thin) and Queen Helen (great smelling but a bit greasy on the saddle) and Shay Butter (nice, but I didn't like the rose scent)
Lately I've been using Walgreen's Therapeutic Moisturizing Creme, a Eucerin knock off. About 6 bucks for a big tub.