I'm already running a 50/34 with an 11-32. I made it through the sustained 12-17% section, but my heart rate was at 90-92% (~185) the whole time, and my cadence was around 50. Doable, but not ideal.

I ride in the Rockies, but even climbs like that are rare, so I'll probably just hammer it out until my respiratory system and muscles catch up. Even then, the 33T would almost make up the 1 tooth difference, allowing me to run a 12-27 instead of a 12-28 on my normal wheels. I really appreciate those smaller gaps in the cassette, and don't mind the bigger gap between the chainrings.