Hand made, to me, suggests that someone actually made the frame set with his or her own hands. A decent hand made bike will look very nice. Smooth thin filed lugs, drops that blend cleanly into fork blades and stays, no silver solder or brass lumps under the paint and things like that.

There are lots of hand made frames that were not crafted as above. Remember, hand made means human involved. Humans make mistakes and, more often than not, the craftsman will correct the mistakes or scrap the project. So, if you see a bike with mistakes (file marks, lugs that don't line up, asymmetry of measurements (example - fork blades not the same length) and other things that look wrong, then the set might be hand made by someone who didn't care or was just having a bad day.

I go into a bit more depth in MY "TEN SPEEDS", where you might want to spend a bit of time learning what makes a good bike, good. I have tried to contain the information in the feature article Bicycle Quality. You might also want to spend a bit of time focusing on other things related to bicycle quality as well as How To Buy Bikes.

And do not be fooled. Nice bikes come from low end and high end builders. I have seen lots of high end Italian, French and English sloppy work.

Hope that is a help.