This past winter I commuted with a 700C hybrid, with Nokian W106 studded tyres. On a couple of occasions we had so much snowfall, it reached up to hub level in snowbanks that accumulated on MUP. I had to walk the bike every now and then until I got to a spot with less snow and was able to gain some momentum again. Observations:

- the plows were busy for several days before the MUP was cleared
- I would have walked the bike a lot more if it had smaller wheels (and walking it would've required more effort)
- OTOH, carrying the bike and multimodal commute would have been an option with a folder, not so with a 700C wheeled bike
- we only have a few days like that per year

In deep snow smaller wheels are a drawback. Depending on your climate (and how quickly your streets get plowed) that may or may not be an issue.

--J