One thing that helped me with the wrist problem was to get weight lifter gloves instead of cycle gloves. Used these for a long time until my wrists got used to the ride. Then I switched to the lighter cycle gloves. Big difference as I could go from riding 10-12 miles to over 20 before any real strain on the wrists. Now I can go much longer without the wrist pain coming on. This was after many adjustments to the bike to get it where I felt good on it. With the seat I was told to give it several hundred miles of break in before doing anything with it. I am still using the same seat and hardly notice it at all anymore. Your body will adjust with time. Constant changes to the set up do not allow your body to adjust to the new setting. Give each setting at least 200 miles or so to see if it works. Then try something else. Good luck on your riding.