I have a set of Pitlocks and use ball bearings stuffed in all the most vital screws through out my LHT. This set up has served me well so far, as I occasionally have to leave it locked up(NY U Lock) in Belltown for 6-10hrs. Each time I arrive to my bike fully intact.
If a thief were to use a portable grinder to get the wheels off, why stop there, might as well focus on the U lock and get the whole thing.