We live on the SE side of Denver. Even if we lived walking distance to a rail station, I can't imagine giving up our one car. We just sold mine and are very happy with the decision to go car-lite, but with a 3yo and an infant, I wouldn't sleep at night with the added stress of knowing that my wife having to lug them around without her car.
More to the point... how do car seats work on buses? How would my wife lug around TWO car seats?