Once you get an abrasion open-sore, it sucks. I posted one time about carrying extra creme to relube, got some flack, BUT IT WORKS. I've been riding a long time, I went to UCSD med school and taught there.
Just try carrying some good chamois creme, if you start to feel irritated, and are getiing off the saddle, try carrying some creme and relubing. If it doesn't work, what have you lost? A minute? But it does work.
Good short chamois pads are also key. I mostly ride Assos FI.Milles, but frankly, Gore Bike Wear Ozons are awesome, DeMarchi Contour Evos are very comfy, all have Assos-Cytech Elastic Interface Technology pads. They all do best with some mid-ride relubes. You're feeling a little abrasion discomfort. You relube. Ahh, that is much more comfy.
In coolere weather riding, you don't notice the issue so much. In hot 85-95 F summer-weather riding, you notice it.