I would build a wheel using Velocity A23 rims. The 23mm wide rim is stiff, strong and light. The added width will pair with either CX tires, winter tires or road tires. If you plan on touring, go with 32 spoke count. I'm 215 lbs and am using a handmade 32 spoke A23/Shimano 105 wheelset with no issues.
http://www.velocityusa.com/default.asp?contentID=746
http://cgi.ebay.com/Velocity-A23-Cus...437#vi-content
Edit: BTW, these wheels are on a size 60 Soma Double Cross DC and the ride quality & handling with 700x25 tires is superb. I would not worry about toe overlap, the bike has a long wheelbase, reducing this problem.