It's different. I (captain) am slower on the tandem than on my single, so rides of the same length take more time, hence are more tiring for me, though much easier for Stoker. There also seemed to be a little more leg wear on this captain for the first few thousand miles until the team got synched up. Stoker and I are lucky in that we ride about the same cadence on our singles, so that was easy for us.
It's trickier to drive because of needing more room to maneuver and stop and also a little more tiring on the captain's shoulders and arms. It took us a lot of practice to be able to stand, but now we can stand together quite well. We worked at it.