Consult your GP if you have one. Or talk w/a sports medicine doctor. Sounds like some sort of blood vessel constriction. Don't ignore it. It could be an indicator of mild thrombosis or a blood clot in your lower leg. Which as you probably know can be precursors to a stroke or pulmonary embolism.

Don't mean to sound alarmist, but it's been my personal experience that a mild physical annoyance can be masking a deeper issue. Make sure you get a sonogram on your lower right leg from the knee down.

Spoke w/my wife re this thread last night and she suggested it may relate to some sort of nerve condition as well. She's a PT. Her reaction was to consult a physician aswell.