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But seriously. Buying lightweight tires and tubes will help a lot. But, they are less durable and might flat easier.

But even more seriouser. The few ounces you lose by spending a few hundred dollars on a new wheelset mean nothing if you are gonna ride in jeans, double straps, and cro-mo bars while wearing a messenger bag.

Going up those hills, ounces are ounces are ounces no matter if they are on the bike or your body.