No. If it is a mountain bike shoe, "SPD Compatible" means it uses the 2-bolt system because Shimano dominates the market. With road shoes you have to look at the sole because some shoes are made with both the 2-bolt and 3-bolt systems, and others are only the 3-bolt. The same 3-bolt pattern works with LOOK and Shimano cleats. I think most Shimano and most low-mid range road shoes are made to work with either cleat, even SPD-R if you are so inclined to use that.

Works with both systems