Riding for utility - SPD's or Eggbeaters
Riding for fitness or racing - Speedplays
Racing - SPD SL's/Look

I started off with SPD SL's and was sick of having to look down at every light to make sure my dura ace pedals were facing the right side up so I moved to Speedplay LA's. Not too happy with the 15 degrees of float so I have some Zeroes waiting to be put on when I have the time to futz around with swapping cleats but they certainly do the job. I've managed to unclip out of my LA's when I was putting out some decent power in some climbs and sprints. I guess this is why they only recommend LA's for recreational riding.