Riding about 5,000 miles a year for five or so years and no failures. Team weight about 290 and not the most powerful team. I never worry about cross-chaining, we almost always shift under load and have been known to shift while standing. I replace the chain when worn which is about 3,000 miles. Cassettes last at least 10,000 miles.
I suggest using Wipperman Connex links. The Shimano - Campy pin replacement method appears weak to me.
Wayne