Hi Canam73...I have 105 shifters. The rear is indexed for 6 speed. If I bought a new wheel I am going to buy a set of 105 brake/shifters. And a new rear derailleur also 105. In another day I would have spent money for Ultegra or Dura-ace. Bought now I spend most my money on my kids. Not to mention I do not think I would see the benefits of the nicer componets until I have ridden for a couple more years.