I have a Brooks B68 on one bike, and a bunch of plastic saddles on my other bikes. Whenever I'll be doing a very long ride, I invariably choose the bike with the Brooks. I can do 80 miles on a Brooks, and be none the worse for wear. I can't say that for any of my other saddles. My best plastic and foam saddle is barely comfortable enough for my 30-mile round trip commute. When that saddle wears out, it'll be replaced with a Brooks.
Durability is also a big selling point of the Brooks. When you buy a foam stuffed saddle, it's the best it's ever going to feel. It's all downhill from there, as the foam breaks down. My Brooks started off feeling very good, and it's only gotten better with use. Years from now, my Brooks will be even more comfortable.
A Brooks is more comfortable and a better value in the long run. It's kind of a no-brainer for people who do a lot of bike riding.