There are a lot of variables - saddle, saddle tilt, fore and aft adjustments, height of seatpost, height of saddle vs. height of bars, amount of weight on butt vs. hands and arms, (what did I forget?)

I've fought numb-butt for decades. My "solutions" include a Brooks saddle, as well as adjusting everything else repeatedly and minimally to arrive at a comfortable setup. However, nothing has completely solved the problem. The "final solution" for me is to get off the bike when my butt starts to hurt. 10-15 minutes off the saddle can give me a good hour pain-free when I get back on.