For the longest time I resisted tubulars as everyone was saying what a pain in the ass they were, etc. I finally bought some, and so far so good. The initial set up takes a couple of hours over a few days, but other than that, I do not find them to be a hassle at all. Pre-glued spare in the jersey, and once you get the technique down, changing out a flat is straight forward. (True, you have to take it easy on the ride home.)
The improvement in ride quality was certainly worth it, and the bike is almost a pound lighter. (I replaced DA 7850 clinchers w/Vittoria open corsa tires)