I've been using a Timbuk2 Bender for the past month and a half and it's been wonderful companion.
It holds my books, binders, laptop, spare clothes and more on the inside and I strap my helmet, jacket (if I think it might rain) and sweaty cycling clothes to the back when walking around. There's a u-lock pocket on the side but I stuff a blender bottle in there.
http://www.youtube.com/watch?feature...&v=nYxX2-nzkIk