IMHO, there is no one answer to these issues, but we can all benefit from understanding the experience of others. I had my first heart attack in 2005. At the time, my total cholesterol was 160, but the LDL/HDL ratio was not good. Post event, I was prescribed a cocktail of drugs, including Vytoren. My total cholesterol dropped to 91, still not good HDL/LDL ratio. For various mostly non-medical reasons, I switched to simvastatin after a couiple of years and my numbers went up to 160 again. Switched back to Vytoren, then had another heart attack in 2010. My numbers then were in the 100 range. Again, for cost and not medical reasons I switched to Crestor and my numbers are in the 110 range, still just ok HDl.LDL range. I have never had issues with statins affecting cycling, but do with other meds (beta blockers). Keep an open mind and do your own research about your specific condition and biology ...