700miles is a big trip. Sounds like it might have been too much everyday even without the allergic reaction given the neck/wrist problems. When I was doing lots of weekend and week trips from the S.F. Bay Area north in my 20's I had my first reaction to something all within 20miles. One eye swelled up shut so I was riding one eyed and as the swelling went down the other eye started swelling shut. There was a hairy ten miles in the middle. Never had that happen before or since but it was worrisome.