I'm confident it would work with indexed; I just happen to like Bar-Cons. I now have them on two of my three derailleured bikes. I may throw a freewheel with ramped cogs on the back to make shifting a little cleaner, but it shifts pretty well as it is. So much better than friction DT shifters. I feel the reach for a rider as tall as I am to get to the DT shifters just put me off balance.