lhorn, The 8S integrated shifter won't work with the 10S. I run Shimano 600 on my roadie and recently swapped in a NOS 53-39 crankset to replace the 53-42 (easier than swapping chainrings) and the difference is noticeable with my 13-23 cassette, but not by a wide margin.
When I rebuilt a roadie to deal with an injured knee I used a 52-42-30 105 triple. This allowed me to keep a close ratio 8S cassette and chainrings and have a bail out gear. This route will require a crankset, BB, long cage RD and shifters. Quite possibly the same parts plus a chain if using a compact and a semi-wide ratio 10S cassette. What is the 10S cassette's gearing?
Brad