I have a work colleague that lives in Laramie/Centennial. He says him and his wife ride road bikes. But I have not been able to pry any more specific information out of him about riding in that area. I think UW has a road cycling team, so I assume people do ride there. Probably mostly from west to east

You might try city-data . com. It's a forum for general discussions, but there may be WY folks on there who live there and may know more.