Road bike or hybrid? If your road bike, 36 spokes, velocity deep v or dyad with the best hubs you can afford. I love the white industries hubs. Great hub at a very reasonable price. If your hybrid, I'd go with dyads or velocity chukkers. Again, 36 spokes, maybe even 40 since you're a big guy and hauling stuff. 36 spokes limits hub selection somewhat and 40 limits it a LOT but you gotta do what you gotta do.