I'm down in the low 200's now, but I was up close to 260 pounds when I got my initial fitting done. It was even a precursor to my buying anything, because I got my fit session and then the fitter and I used that information to determine which bikes in the shop were a reasonable match for my fit, ride style, and price range.
Things haven't changed too far on the fit even as I've changed body composition and ride style; from fairly big and doing mid distances like 100k, to still fairly big at 235 and riding 400k in a single day, to where I am now and back to only riding 100 - 110k for distance but doing it a lot faster.
There hasn't been anything acting as a majour hinderance after changing body composition that makes the original frame measurements unusable. The only component I've needed to change was the stem.
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"I feel like my world was classier before I found cyclocross."
- Mandi M.