get a professional fit. It will be well worth every penny, period.

here's my BLIND advice:
adjust yourself before you ride, assuming you use cycle shorts/bibs.
change angle of seat: (assuming your seat height and bb fore/aft is correct)
nose up to equalize hand/nut pressure if your rotating from the hips not the back.
raise your bars if your bending over with your back.
after pedaling for a bit your feet swell up try loosen your shoes toe strap