+1. I've tried several belted tires. Armadillos, TourGuards, etc.

None were as dependable as Mr. Tuffy.

Wipe your tires often and that helps reduce flats quite a bit. A piece of glass can slowly work through a belted tire or a Mr. Tuffy but if you wipe it off before it has a chance to dig then you'll save yourself a flat.

Be careful when you replace tubes. Make sure you get the offender out of the tire. And go around the tire squeezing it before inflation, making sure you can see rim strip when you squeeze it. If you see tube, try wiggling tire back and forth to see if you can get the tube all the way in the tire. Try putting a little air in there, then wiggling a little more, deflate, wiggle, another blast of air, 'til you cant see any tube under the tire bead.

I sometimes do a 100 mile ride with about 80 miles freeway. If you've ever been on a freeway shoulder you'll know that trip is hell on tires. I bring a patch kit, two spare tubes and a spare tire on that one, just in case.